How is recessive disorder inherited

Review provided by VeriMed Healthcare Network. Editorial team. Autosomal recessive. Alternative Names. Genetics - autosomal recessive; Inheritance - autosomal recessive. Autosomal recessive X-linked recessive genetic defects Genetics. Health Topics A-Z Read more. Easy-to-Read Materials Read more. Other chapters in Help Me Understand Genetics. Genetics Home Reference has merged with MedlinePlus. Learn more. The information on this site should not be used as a substitute for professional medical care or advice.

Contact a health care provider if you have questions about your health. What are the different ways a genetic condition can be inherited? From Genetics Home Reference. These conditions are usually inherited in one of several patterns, depending on the gene involved: Patterns of inheritance Inheritance pattern Description Examples Autosomal dominant One altered copy of the gene in each cell is sufficient for a person to be affected by an autosomal dominant disorder.

Huntington disease , Marfan syndrome Autosomal recessive In autosomal recessive inheritance , variants occur in both copies of the gene in each cell. Y chromosome infertility , some cases of Swyer syndrome Codominant In codominant inheritance , two different versions alleles of a gene are expressed, and each version makes a slightly different protein.

ABO blood group, alpha-1 antitrypsin deficiency Mitochondrial Mitochondrial inheritance , also known as maternal inheritance, applies to genes in mitochondrial DNA.

Leber hereditary optic neuropathy LHON Many health conditions are caused by the combined effects of multiple genes described as polygenic or by interactions between genes and the environment. Topics in the Inheriting Genetic Conditions chapter What does it mean if a disorder seems to run in my family? Why is it important to know my family health history? If a genetic disorder runs in my family, what are the chances that my children will have the condition? When they lose their oxygen, they form into the shape of a sickle, or the letter "C.

The cluster causes a blockage and stops the movement of healthy, normal, oxygen-carrying blood. This blockage is what causes the painful and damaging complications of sickle cell disease. Sickle cells live only for about 15 days. Normal hemoglobin cells can live up to days. Sickle cells risk being destroyed by the spleen because of their shape and stiffness. The spleen helps filter the blood of infections.

Sickle cells get "stuck" in this filter and die. Due to the decreased number of hemoglobin cells circulating in the body, a person with sickle cell is chronically anemic. The spleen also suffers damage from the sickle cells, which block the healthy oxygen-carrying cells. After repeated blockages, the spleen is very small and does not work properly.

Without a functioning spleen, these people are more at risk for infections. What are the different ways in which a genetic condition can be inherited? National Library of Medicine. If a genetic disorder runs in my family, what are the chances that my children will have the condition? Fact Sheet 12 Mitochondrial inheritance. Center for Genetics Education. Cleveland Clinic. Leber hereditary optic neuropathy sudden vsion loss. National Organization for Rare Disorders. Swyer syndrome. NSW Government Health.

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I Accept Show Purposes. Table of Contents View All. Table of Contents. Patterns of Inheritance. Two primary factors influence the likelihood a person will inherit a genetic disorder: Whether one copy of the mutated gene from either parent is passed down or whether two copies one from both parents are passed down Whether the mutation is on one of the sex chromosomes X or Y or on one of 22 other pairs of non-sex chromosomes called autosomes. Genetic Testing for Huntington's Disease.

Living With Sickle Cell Disease.